The Future of
Musculoskeletal Research
At MSK Doctors Research, we bridge the gap between academic innovation and real-world clinical care. From AI-powered motion analysis to 10-year implant durability studies, our work defines the standards of joint preservation and functional longevity.
A Network of Excellence in
Clinical Innovation
Clinical Research Programmes
Current Studies &
Active Clinical Trials
Our ongoing research initiatives focus on long-term patient outcomes, innovative implant technologies, and the validation of digital health tools within UK orthopaedic care.
A prospective controlled clinical study exploring whether targeted, non-invasive EMS can reduce early quadriceps wasting and support functional recovery after knee surgery.
Methodology
Non-Invasive EMS
Focus Area
Muscular Atrophy
Lead Partner
MSK Research Lab
A prospective non-interventional programme tracking real-world function, implant integrity, and patient-reported outcomes over 10 years after U2 MB™ knee replacement.
Follow-up
10 Years
Design
Non-Interventional
Population
UK Focus
A structured 24-week pathway evaluating non-compressive, drug-free therapy for Achilles tendinopathy, including serial imaging and functional monitoring.
Protocol
24 Weeks
Imaging
2 Open MRI Scans
Therapy
100% Drug-Free
Emerging Clinical Initiatives
Upcoming Research
Programmes currently being structured for clinical launch, with study design, functional recovery targets, and partner delivery pathways already taking shape.
Upcoming Programme
SENSUIT™
Space-Health Innovation for Musculoskeletal Monitoring
MSK Doctors is advancing SENSUIT™ as a translational innovation programme combining AI, smart textiles, and the MAI Motion Platform to deliver continuous musculoskeletal insight from extreme environments to preventative healthcare on Earth.
Capability
AI Driven
Interface
Smart Textiles
Platform
MAI Motion
Completed Studies & Programmes
Evidence That
Compounds Over Time.
A published foundation spanning long-term arthroplasty follow-up, Innovate UK-funded digital health programmes, wearable innovation, and internationally-recognised AI motion analysis.
Cureus 2026
Squat Validation
Empirical Validation Using MAI Motion
Cureus 2026
UniReliever® Brace
Dynamic Offloading Measured with MAI Motion
24-Month Cohort
Arthrosamid Knee OA Study
A PROMs-Based 24-Month Prospective Cohort Study
10-Year Outcomes
EVOLUTION® NitrX™
10-Year Multicentre Clinical Follow-Up
24-Month Programme
MSK Digital Platform
Innovate UK Knowledge Transfer Partnership
18-Month Programme
Smart-MOTION®
Innovate UK Biomedical Catalyst — £480,000
Santander X 2025
MAI Motion
Santander X Global Challenge — Top 10 Finalist
Front. Digit. Health 2024
Motion-Based Biomarkers
A Marker-less Human Motion Analysis System
Published Study
Sit-to-Stand Validation
Empirical Validation Using MAI Motion
J Arthritis 2022
Marker-less Motion Capture
A Low-Cost Human Motion Analysis Method
Conferences & Presentations
Where Clinical Questions
Meet International Scrutiny.
Across Paris, Casablanca, the British Orthopaedic Association Annual Congress and the European osteoarthritis symposium in Porto, the 2025 programme linked surgical decision-making with markerless movement measurement and quantitative imaging.
01 · Surgical Innovation
The Human Algorithm
Designing Knee Surgery through Robotics, Motion and Biology
02 · Motion Intelligence
MAI Motion
The Future of Musculoskeletal Health and Movement
03 · Functional Biomechanics
Sit-to-Stand vs Squat
Biomechanical Comparison Using the CRAFT Framework and MAI Motion Analysis
04 · Orthobiologics
Motion after Orthobiologic Injections
Does Markerless Motion Analysis Predict Movement Quality after Intra-articular Orthobiologic Injections?
05 · Quantitative Imaging
onMRI
AI-powered Objective MRI Analysis for Quantifiable Musculoskeletal Imaging
06 · Post-Operative Recovery
Electrical Muscle Stimulation After Knee Replacement
Preserving Quadriceps Volume and Early Function After Unilateral TKR
07 · Cartilage Repair
ChondroFiller for Knee Cartilage Defects
Early Clinical Outcomes of a Single-Stage Collagen Gel
08 · Cartilage Repair
ChondroFiller for Ankle Cartilage Defects
Clinical and Imaging Outcomes in Focal Talar Dome Lesions
09 · Motion Analysis
Knee OA Severity and Hip Movement Quality
C.R.A.F.T. Scores Across Kellgren–Lawrence Grades in 177 Patients
The Innovation Pipeline
Programmes developed for competitive funding routes and continuing to evolve within our active innovation pipeline. These initiatives represent our commitment to pushing the boundaries of musculoskeletal science.
MAI-KNEE™
Precision Motion Analysis with Anatomical Integration
Extends the clinically validated MAI Motion platform into a multi-modal diagnostic framework, combining AI-driven 3D motion analysis with anatomical MRI insight to generate interpretable digital biomarkers and enable earlier stratification of knee osteoarthritis. Architected for regulatory progression as a Class II medical device deployable on standard mobile devices.
S.M.A.R.T. KneeMotionAI™
Motion-Informed Intelligence for Personalised Knee Replacement
Brings real-world knee motion intelligence into replacement planning, capturing dynamic 3D movement with standard cameras to inform alignment and implant strategy. Introduces Real-Life Kinematic (RLK) insight, moving beyond mechanical and kinematic alignment by using functional motion data rather than static scans alone.
D.R.E.A.M. KneeAI™
Dynamic Intelligence for Knee Surgery
A surgical-planning research concept designed to bring real-world movement into the pre-operative assessment of knee replacement. Uses MAI Motion to derive a digital kinematic signature from markerless 3D capture and translate it into personalised alignment insight — an approach the programme describes as Real-Life Kinematic Alignment.
MAI-MRI™
Integrated AI for Early Knee Osteoarthritis Intelligence
Unites automated AI-based MRI biomarker extraction with markerless 3D motion analysis, connecting how the knee looks with how it behaves. Aims to identify early cartilage degeneration, detect biomechanical imbalance and stratify progression risk — reducing unnecessary MRI referrals and diagnostic delay.
KneeMRI-MAI™
Multimodal AI for Structural–Functional Osteoarthritis Intelligence
Developed with AI researchers at the University of Exeter, bridging the structural–functional divide through deep-learning MRI segmentation and motion-derived biomarkers. A working prototype has demonstrated feasibility at TRL4, with development advancing toward a Class IIa medical device pathway.
MAI-KNEE™ Digital Phenotyping
Multimodal AI for Knee Osteoarthritis
An 18-month multimodal programme proposed by Actomed with the University of Exeter, designed to connect what the knee looks like on MRI with how it behaves in everyday movement. Combines AI-assisted cartilage and meniscal analysis with markerless motion to generate interpretable digital biomarkers for earlier stratification.
NUMWRS™
A Motion Waveform Rating Scale for Knee Stability
A proposed 12-month, non-interventional study for the Royal College of Surgeons of Edinburgh, testing whether the n-u Motion Waveform Rating Scale — six named patterns read from markerless motion traces — corresponds to clinically meaningful differences in knee function and alignment behaviour.
iFAST Motion Age
A Digital Biomarker for Multimorbidity Risk
A 12-month NIHR iFAST plan with the University of Exeter, asking whether Motion Age — an age-equivalent movement score derived from a sit-to-stand video — can predict elevated multimorbidity risk in adults with musculoskeletal conditions when benchmarked against the Clinical Frailty Scale.
KNEE-MotionMRI
Predictive AI for Early Knee Osteoarthritis Stratification
A six-month Keep Clinic feasibility programme proposed to Innovate UK Growth Catalyst, fusing smartphone motion analysis with MRI-derived structural features to stratify knee osteoarthritis before irreversible damage appears on imaging.
MRI-MAI™
Deep Tech Stratification of Musculoskeletal Disorders
An 18-month EIC Accelerator proposal to take the Reverse AI™ engine from validated prototype to CE-marked product, fusing motion biomarkers with machine-learning MRI analytics across a pan-European network in Italy, France, Türkiye and Romania.
UK–Korea Smart Textiles
OLED Clothing for Whole-Limb Motion Analysis
A 30-month five-partner programme with the University of Leeds, KAIST, Incheon National University and MCell, embedding strain-triggered colour-change OLED into smart clothing so MAI Motion can read force as light across the whole limb rather than at fixed joint points.
Academic & Clinical Collaboration
We are actively seeking strategic partners and academic consortiums to accelerate these programmes towards clinical reality.
For Our Patients
Advancing Medicine.
Empowering Recovery.
At MSK Doctors Research, we believe that private healthcare should be more than just service—it should be the engine of medical progress. We bridge the gap between laboratory innovation and clinical excellence, ensuring our patients are the first to benefit from evidence-led, future-proof orthopaedic care.
Evidence-Led Decisions
We move beyond "opinion-based" medicine. Every surgical technique and implant we offer is backed by rigorous data and peer-reviewed research.
Safety & Governance
Patient safety is our absolute priority. Our research adheres to the highest UK ethical standards, ensuring innovation never compromises care.
Global Impact
By choosing us, you are part of a global movement. Your journey contributes to the data that will define orthopaedic standards for the next generation.
Next-Gen Technology
We invest in non-invasive tracking and biological solutions, aiming to restore your lifestyle with less effort and more insight into your recovery.
100%
Evidence Driven
UK-Based
Clinical Research
"Our mission is to ensure that every patient benefits from the most advanced, safe, and effective musculoskeletal treatments available globally."